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t-Virus (short for "Tyrant Virus") was the collective name for a series of artificial mutagen RNA viruses designed as weaponized variants of the Progenitor Virus for military application. They inherited the DNA mutation property of the Progenitor Virus and drastically improved on it. The t-Virus is capable of inducing sudden mutations on a host and is the raw material most suitable for biological weapons creation. Upon infection, it rewrites DNA and mutates the host into a creature with different properties and abilities which cannot be found in the natural world.

The Anti-Umbrella Pursuit and Investigation Team was a top-secret special military agency within U.S.STRATCOM (United States Strategic Command) under the direct control of the U.S. President. It took charge of intelligence gathering, security activities and special operations with the primary mission of gathering information about biological weapons and producing effective countermeasures while investigating the activities of the Umbrella Corporation and related elements.

The G-virus (short for "God virus") was a powerful virus developed by Dr. William Birkin with potential surpassing that of the t-virus. Its main function was the creation of "G-Creatures", a new life form designed for use as a B.O.W. (Bio Organic Weapon) that could breed through sex. However, at some point during its development, its focus turned to its potential for creating "G-Humans", a superior human race. Following its recovery from Raccoon City, it fell into the hands of several organizations.

Morpheus is the colloquial name for the Tyrant form of Morpheus D. Duvall. After injecting himself with the refined agent V.0.9.2. of the experimental t+G-virus, Duvall adapted to the virus, becoming an intelligent Tyrant.

The t+G-virus (short for Tyrant+God virus) was a hybrid virus with electrical properties developed by the Umbrella Corporation by fusing the t-virus and G-virus and resolving some of their more volatile attributes. Its primary goal was the introduction of an extra defense for infected creatures in the form of an extremely high-voltage electromagnetic barrier.