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Virus Classification

Group: Group VI (Reverse Transcribing)
Family: Retroviridae
Genus: Unknown


Uroboros Virus

The Uroboros virus was an RNA retrovirus developed by TRICELL based on the Progenitor virus. It was the main part of the Uroboros Project advanced by Albert Wesker and adapted only to humans with excellent genes. Its adaptation rate was extremely severe and most hosts died.

Although it was an artificial variant of the Progenitor virus, it was not classified as a t-virus strain since it was not developed by the Umbrella Corporation.


On December 4, 1966, Oswell E. Spencer and others discovered the Progenitor virus within a rare flower found only in an isolated underground cave system in the nation of Kijuju, West Africa. The top-secret Umbrella Africa Laboratory was built to facilitate research, production and shipping of the virus to the company's various facilities. In November 1998, the laboratory was shut down to conceal the virus.

In 2006, Albert Wesker killed Spencer upon learning of his true goal to become the god of a utopia containing a new superhuman species created with the Progenitor virus. Wesker took over the plan and returned to an alliance with Excella Gionne to use her corporate strength to find the Progenitor virus. She took office as managing director of the TRICELL Africa Branch and first restored the Umbrella Africa Laboratory, which was essential to the Uroboros Project. After the restoration was complete, she secured research funds to develop the virus by marketing B.O.W. (Bio Organic Weapons) using her pawn Ricardo Irving. 1

On May 8, 2007, development of the Uroboros virus began with the goal to surpass the G-virus and t-Veronica virus by eliminating the defects of excessive mutation, instability and brain damage while ignoring retention and rejection rate. TRICELL researcher Miguel found immediate solutions to two of those defects, but the remaining one required further time. 2 However, development of the virus ran into difficulties beyond expectation. The initial strain derived from the Progenitor flower was too fatal to use. Far from promoting human evolution, it merely killed any and all humans indiscriminately. A major breakthrough was found in "Test Subject No.1" Jill Valentine, captured by Wesker in 2006. He kept her alive in a cryogenic state to exact revenge on her as the virus' first test subject upon completion. However, the sensors monitoring her vital signs detected abnormal values.

As a result of examination, the presence of a mutant t-virus strain within her body was confirmed, a remnant of the t-virus she was exposed to in the Arklay Laboratory and the strong form she was infected with in Raccoon City by the Nemesis-T Type. The recombined virus wasn't expelled completely by the vaccine and lay dormant continuing to grow. It reactivated in her long cryogenic sleep but soon vanished. Afterwards, strong antibodies with high purity were found in her body which produced a self-defense capability against the incubating virus. Wesker used these antibodies to weaken the Uroboros virus and kept her alive as a living factory for the antibodies. 3

The final aspect of the Urobros Project was to launch missiles carrying the virus from a bomber plane upon arrival in the tropopause. The virus dispersed from the missiles would be carried on the westerlies flowing through the upper troposphere and the selection would take root all over the world. As a countermeasure against the potential creation of massive Uroboros creatures from failed hosts, the Shango Laser Satellite was constructed and sent into orbit by TRICELL. 4

On May 6, 2008, a leak of the virus occurred during a test loading onto missiles. Local cockroaches were exposed to the Uroboros virus producing the irregular mutant Reaper, a rare case exhibiting the virus' influence to a limited extent. 5

On March 6, 2009, all personnel attached to the Uroboros Project were executed and incinerated. 6 The next day, Chris Redfield and Sheva Alomar successfully stopped the bomber from launching the missiles into the atmosphere and killed Wesker. Samples of the virus were later recovered from Africa by the research team of Alex Wesker. The researchers tested its effects on corpses by direct injection and discovered that it could reanimate them.

In 2011, the U.S. Congress discussed the danger posed by the virus. Neil Fisher came into contact with Alex Wesker and negotiated to provide TerraSave employees as potential hosts in her "rebirth ceremony" on Sushestvovanje Island in exchange for an Uroboros virus sample. She betrayed Fisher and injected him with the virus instead. Six months later, she used the virus to create the B.O.W. Revenant and others to kill the rebirth host Natalia Korda. She injected herself with a sample of the virus in order to overcome her fear of facing her "other self" in Korda. She was killed and the remainder of the virus on the island was exterminated by the BSAA (Bioterrorism Security Assessment Alliance).


The Uroboros virus was developed to resolve the fatal defects of the G-virus and t-Veronica. The virus was designed to be unable to cause freak mutations on its own, as this would invalidate the goal to create a new superhuman species by creating genetically incompatible creatures unable to breed.

The most notable physical side-effect of the virus was the creation of vermicular viral cysts within a host's body which, in the case of failed adaptation, could then emerge and self-propagate by absorbing organic material using the host's severely body as a vehicle for movement. The virus could also create at least one large yellow/orange organ within the body as the core for this organic propagation.

Injection (Live)

Injection of the virus into a live host resulted in a DNA selection process as the virus identified excellent genes. After injection, the host exhibited sweating, disordered breathing, delirium and confusion. In the case of rejection, the host's eyes clouded black before discharging the viral cysts to consume the host's body from the inside out.

Injection required certain strict dosage levels according to a host's body weight. Over sixty kilograms required one dosage, over forty kilograms required an approximately two-thirds dosage, over twenty kilograms required approximately half dosage while under twenty kilograms required one-third dosage. Missiles carrying the virus contained carefully calibrated amounts to ensure adequate dosage to a population. 7

Upon adaptation the virus' activity would calm down and the cysts would regress into the body. Successful adaptation with the virus resulted in superhuman abilities and the formation of the same slitted yellow eyes found in Progenitor virus adaptation. These abilities included increased strength, speed, jumping power, enhanced skeletal and muscle strength and a significant regeneration ability. However, it was unknown if the Progenitor virus' traits of immortality and increased intelligence were achieved.

If a host possessed adaptable genes but overdosed or was already infected with another virus such as the t-Phobos virus, the Uroboros virus would be restrained by the host and incapable of consuming them. The host could control the viral cysts and retain whatever intelligence they had prior to infection at the cost of extreme aggression, loss of reason and a severe transformation of the body. In these cases, the virus' organic propagation core was a transformation of the heart and was a critical weak point. Excessive damage to a host caused the virus to go out of control in an effort to heal, replacing entire body parts with viral cysts in the process.

Injection (Dead)

Injection of the virus into a corpse resulted in crude reanimation. The virus created a large yellow/orange core within the body and then reorganized organic material around that core, thereby reanimating the corpse. The core served as the control center of the organic growth and destroying it negated the reanimation process. The core's placement varied between hosts. 8

Similar to resurrected hosts of the G-virus and C-virus, dead hosts had no ability to transform or propagate compared to live hosts due to the lack of ATP (adenosine triphosphate) in dead cells, a cellular coenzyme vital to cell division and motility. This type of host remained in a state of living death with no potential for transformation or re-mutation.

Secondary Infection

Secondary infection with the Uroboros virus was documented with the irregular mutant Reaper, a cockroach exposed to traces of the virus. It exhibited exponential growth to roughly human-size with several bulbous organs formed by the virus and a special gas able to interfere with another creature's vision. Whether or not these effects were unique or common is unknown due to the lack of varied infection cases.


Uroboros is the Serbo-Croation form of "ouroboros." It refers to the ancient Greek symbol of a serpent or dragon devouring its own tail, symbolizing self-reflexivity, cyclicality, eternal return and the circular nature of the alchemist's (Albert Wesker's) work.


  1. 1. No. 11 Excella Gionne
  2. 2. TRICELL Researcher Miguel's Journal 2
  3. 3. No. 10 Jill Valentine
  4. 4. Uroboros Project Execution Document
  5. 5. About the Mutated Organism in the Facility
  6. 6. Information Leak Countermeasure Implementation Report
  7. 7. Uroboros Virus Usage Advisory
  8. 8. Report on the Uroboros Virus